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Variation in human water turnover associated with environmental and lifestyle factors
Journal
Science
ISSN
0036-8075-1095-9203
Date Issued
2022-11-25
Author(s)
Yosuke Yamada
Xueying Zhang
Mary E. T. Henderson
Hiroyuki Sagayama
Herman Pontzer
Daiki Watanabe
Tsukasa Yoshida
Misaka Kimura
Philip N. Ainslie
Lene F. Andersen
Liam J. Anderson
Lenore Arab
Issad Baddou
Kweku Bedu-Addo
Ellen E. Blaak
Stephane Blanc
Alberto G. Bonomi
Carlijn V. C. Bouten
Pascal Bovet
Maciej S. Buchowski
Nancy F. Butte
Stefan G. Camps
Graeme L. Close
Jamie A. Cooper
Richard Cooper
Sai Krupa Das
Lara R. Dugas
Simon Eaton
Ulf Ekelund
Sonja Entringer
Terrence Forrester
Barry W. Fudge
Annelies H. Goris
Michael Gurven
Lewis G. Halsey
Catherine Hambly
Asmaa El Hamdouchi
Marije B. Hoos
Sumei Hu
Noorjehan Joonas
Annemiek M. Joosen
Peter Katzmarzyk
Kitty P. Kempen
William E. Kraus
Wantanee Kriengsinyos
Robert F. Kushner
Estelle V. Lambert
William R. Leonard
Nader Lessan
Corby K. Martin
Anine C. Medin
Erwin P. Meijer
James C. Morehen
James P. Morton
Marian L. Neuhouser
Theresa A. Nicklas
Robert M. Ojiambo
Kirsi H. Pietiläinen
Yannis P. Pitsiladis
Jacob Plange-Rhule
Guy Plasqui
Ross L. Prentice
Roberto A. Rabinovich
Susan B. Racette
David A. Raichlen
Eric Ravussin
Leanne M. Redman
John J. Reilly
Rebecca M. Reynolds
Susan B. Roberts
Albertine J. Schuit
Luis B. Sardinha
Analiza M. Silva
Anders M. Sjödin
Eric Stice
Samuel S. Urlacher
Giulio Valenti
Ludo M. Van Etten
Edgar A. Van Mil
Jonathan C. K. Wells
George Wilson
Brian M. Wood
Jack A. Yanovski
Alexia J. Murphy-Alford
Cornelia U. Loechl
Amy H. Luke
Jennifer Rood
Klaas R. Westerterp
William W. Wong
Motohiko Miyachi
Dale A. Schoeller
John R. Speakman
DOI
10.1126/science.abm8668
Abstract
<jats:p>
Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (
<jats:sup>2</jats:sup>
H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.
</jats:p>
Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (
<jats:sup>2</jats:sup>
H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.
</jats:p>
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