Abdul-Hanan Saani InusahAndrew Mpagwuni ZiblimMichael Boah2025-06-042025-06-042025-05-30https://doi.org/10.1186/s12905-025-03816-xhttps://dspace.ughe.org/handle/123456789/563Background Sex work in Ghana is deeply intertwined with economic hardship, criminalization, and social stigma, which subjects female sex workers (FSWs) to significant vulnerabilities. In Ghana, many FSWs, particularly immigrants, face compounded challenges, including physical and sexual abuse, police harassment, and discrimination, which are exacerbated by their migrant status. This study aims to address the gap in understanding the specific lived experiences of transnational FSWs in Ghana, with a focus on the intersection of gender, migration, and economic vulnerability. Methods This study utilized a qualitative phenomenological approach to explore the lived experiences of transnational FSWs in Ghana’s two largest cities, Accra and Kumasi. Participants were purposively selected through snowball sampling technique until thematic saturation was achieved, interviewing fourteen FSWs. In-depth interviews were conducted in English. Data collection took place in November and December 2024, with basic demographic data gathered at the beginning of each interview, and thematic analysis was employed to analyze the anonymized transcripts. Results Economic necessity was the primary driver behind migration and entry into sex work for FSWs, with many revealing that promises of legitimate employment often led to coerced involvement into the trade. Participants also reported high levels of violence, including physical assault, theft, and sexual coercion from clients, often in isolated locations. They also experienced harassment and exploitation by law enforcement, which compounded their vulnerability. Additionally, discrimination based on nationality also exacerbated their vulnerability, as foreign FSWs were often treated more harshly than their Ghanaian counterparts by clients, police, and the public. Conclusion This study’s findings highlight the urgent need for comprehensive policy reforms that address the root causes of migrant sex work, including better economic opportunities for women and the decriminalization or regulation of sex work to protect sex workers from the risks associated with its illegal status, such as police harassment, exploitation, and lack of legal protections.enFemale sex workersViolenceExploitationGhanajournal-article