Sudi JemalEngidaw FentahunMohammed OumerAbebe Muche2025-03-052025-03-052021-06-3010.1186/s13052-021-01093-6https://dspace.ughe.org/handle/123456789/432<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Congenital anomaly is a partial or complete structural and/or functional defect during intrauterine life. Globally, major congenital anomalies account for 6% of all newborns among which about 94% of cases occurred in developing countries. In spite of its public health importance, very limited studies are reported in Ethiopia, and hardly any study in Arsi Zone.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To determine the predictors of congenital anomalies among newborns in Arsi Zone Public Hospitals, Southeast Ethiopia.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A multi-center institutional-based case-control study was conducted in 418 (105 cases and 313 controls) of newborns in Arsi Zone Public Hospitals. Descriptive analysis, binary and multivariable logistic regressions were implemented.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In this study, women who have been drinking alcohol during pregnancy were 3.48 times more prone to have newborns with congenital anomalies than their counterparts (AOR = 3.48; 95% CI: 1.38, 8.74). The likelihood of having a newborn with congenital anomalies was six and four times higher for women who had a maternal illness (AOR = 6.10; 95%CI: 2.39, 15.57) and chewing khat during pregnancy (AOR = 4; 95%CI: 1.49, 10.65), respectively. Moreover, the lack of folic acid supplementation and pesticides during pregnancy were 3.25 and 4.76 times more likely to experience a newborn with congenital anomalies, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Alcohol drinking, maternal illness, khat chewing, and chemical exposure during pregnancy had a significant association with the occurrence of congenital anomalies. While, taking folic acid supplements had a protective effect. Health experts and the community should take these factors into consideration and act accordingly.</jats:p></jats:sec>enCongenital anomaliesPregnancyFolic acidPesticidesPublic hospitalsEthiopiajournal-article