Burhan KantawalaNagham RamadanYoumna HassanViolette FawazNadine MugishaAbubakar NazirMagda WojtaraOlivier Uwishema2025-06-172025-06-172023-08https://doi.org/10.1002/hsr2.1524https://dspace.ughe.org/handle/123456789/644The brain is a vital organ responsible for motor and sensory functions as well as complex processes like perception, learning, and emotions. Maintaining brain health is crucial, and it can be achieved through the increasing physical activity, preventing metabolic syndrome, preserving mental health, and improving sleep quality. Physical activity encompasses a wide range of exercises, from walking to intense sports, which contribute to cerebral blood flow, a healthy sympathetic system, and cellular brain regeneration. Neglecting physical activity can lead to various neurological diseases, affecting around one billion people worldwide. The abandonment of prevention at different levels worsens the situation, including negligence of key factors, lack of preventive programs, and inadequate health care systems.1 This correspondence focuses on the role of physical activity interventions in preventing neurological diseases.journal-article