Xiao-Xi ZhangZohar LedermanLe-Fei HanJanna M. SchurerLi-Hua XiaoZhi-Bing ZhangQiu-Lan ChenDirk PfeifferMichael P. WardBanchob SripaSarah GabriëlKuldeep DhamaKrishna Prasad AcharyaLucy J. RobertsonSharon L. DeemCécile AenishaenslinFilipe Dantas-TorresDomenico OtrantoDelia GraceYang WangPeng LiChao FuPatrícia PoetaKokouvi KassegneYong-Zhang ZhuKun YinJiming LiuZhao-Jun WangXiao-Kui GuoWen-Feng GongBernhard SchwartländerMing-Hui RenXiao-Nong Zhou2025-03-072025-03-072024-04-1210.1186/s40249-024-01198-0https://dspace.ughe.org/handle/123456789/455Background: Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest impact. Main text: This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health implementation. Conclusions: By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.enGlobal HealthOne HealthOne Health Action CommissionResearch agendajournal-article