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Disease Severity of Children Attending the Pediatric Sickle Cell Clinic of a Tertiary Health Institution in Southwest Nigeria
Journal
Nigerian Journal of Basic and Clinical Sciences
ISSN
0331-8540
Date Issued
2024-01-24
Author(s)
Yetunde T. Olasinde
Rasheed O. Ibrahim
Ademola Abolarin
Abimbola O. Odeyemi
Adeola Olasinde
Olabimpe O. Kofoworade
Victor Adeagbo
Efeturi Agelebe
Daniel A. Gbadero
DOI
10.4103/njbcs.njbcs_58_23
Abstract
Context:
Sickle cell disease is the most common hemoglobinopathy worldwide. Its effects are pan-systemic, affecting every organ in the body; hence, the manifestations are variable and diverse. A scoring parameter is needed to group patients into similar severity brackets for prognostic purposes.
Aim:
This study aimed to determine the severity score of children attending the Pediatric sickle cell clinic of a tertiary institution using an existing set of scoring parameters.
Materials and Methods:
This was a cross-sectional study that involved 100 children attending the sickle cell clinic of a tertiary institution in Nigeria. We used semi-structured questionnaires to obtain relevant sociodemographic data. We determined the clinical severity of the population using a set of clinical-laboratory parameters. Data were analyzed using IBM Statistical Package for Social Sciences version 25.0 for Windows. The level of significance was set at P < 0.05.
Results:
Most of the children (80; 80%) had a mild index of disease severity. Age, gender, and social class did not significantly affect disease severity. However, a low white blood cell (WBC) count predicted mild disease severity.
Conclusion:
Our study showed that most of the children had a mild index of disease severity, and this was predicted by a low WBC count.
Sickle cell disease is the most common hemoglobinopathy worldwide. Its effects are pan-systemic, affecting every organ in the body; hence, the manifestations are variable and diverse. A scoring parameter is needed to group patients into similar severity brackets for prognostic purposes.
Aim:
This study aimed to determine the severity score of children attending the Pediatric sickle cell clinic of a tertiary institution using an existing set of scoring parameters.
Materials and Methods:
This was a cross-sectional study that involved 100 children attending the sickle cell clinic of a tertiary institution in Nigeria. We used semi-structured questionnaires to obtain relevant sociodemographic data. We determined the clinical severity of the population using a set of clinical-laboratory parameters. Data were analyzed using IBM Statistical Package for Social Sciences version 25.0 for Windows. The level of significance was set at P < 0.05.
Results:
Most of the children (80; 80%) had a mild index of disease severity. Age, gender, and social class did not significantly affect disease severity. However, a low white blood cell (WBC) count predicted mild disease severity.
Conclusion:
Our study showed that most of the children had a mild index of disease severity, and this was predicted by a low WBC count.
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