Dr Royhaan-Folarin

Aim:This study investigated the neurobehavioral and micro structural anti-anxiety potential of flaxseed oil following rotenone-induced Parkinson’ disease [PD] in mice. Study Design: Fifty-six adult male and female mice (Mus musculus) weighing between 23.9-26.3 grams were used for this study. The mice were randomly placed into four groups of fourteen mice each: A (Control; mice pellets), B (Rotenone 3mg/kg, IP), C (Rotenone + Flaxseed oil 0.3ml orally), and D (0.3ml Flaxseed + Rotenone). Place and Duration of the Study: Department of Anatomy, Olabisi Onabanjo University. Between May and September, 2016.Original ResearchArticle. Methodology: The brains were excised, weighed and appropriate sections taken and processed histology and labelled with H&E, silver and Nissl stains and immuno-cytochemically with GFAP. Results: The results showed significant (P<0.005) increase in anxiety related activities and neuronal structural derangement, and degeneration of astrocytes in the rotenone-induced Parkinson’s mice, which were counter/ameliorated by flaxseed oil treatments. Conclusion: In conclusion, flaxseed oil acts as a neuro-protective agent against the insult of rotenone model of Parkinson’s disease, thus it should be further evaluated as a potential therapeutic candidate in the management/treatment of Parkinson's disease